chlamydia treatment failure with azithromycin


The size of the circles represents the precision of each study. 2014 Jul 15;59(2):193-205. doi: 10.1093/cid/ciu220. A Pooled estimate of failure rate in azithromycin user based on a random… A Pooled estimate of failure rate in azithromycin user based on a random… A Pooled estimate of failure rate difference (failure rate in intervention - failure… Results of meta-regression on the relation between failure rate in azithromycin user and… Results of meta-regression on the relation between failure rate difference and age. The midpoint of each line segment shows the failure rate difference, the length of the line segment indicates the 95% confidence interval in each study, and the diamond mark illustrates the pooled estimate.Results of meta-regression on the relation between failure rate in azithromycin user and age. The study design of this Phase III trial will address major limitations of prior chlamydia efficacy studies and the findings will reveal both the true efficacy of azithromycin and doxycycline in uncomplicated chlamydia in adolescents and the factors that predict treatment failure. Free PMC article
While most repeat positive cases are likely to be reinfections, emerging evidence indicates treatment failure … Consenting chlamydia-positive subjects at the enrollment visit (study visit 1) will be enrolled, asked to provide demographic data, to provide a first-void urine sample (not a mid-stream specimen) for repeat chlamydia testing with Gen-Probe (GP) AC2 (for verification of chlamydia), and then randomized to 1 of 2 treatment arms (190 153 subjects per arm): doxycycline 100 mg PO BID for 7 days or azithromycin 1 gm PO single dose. doi: 10.1002/14651858.CD010485.pub2.Pharmacoeconomics. This site needs JavaScript to work properly. This study is designed primarily to determine the frequency of chlamydia treatment failure following either azithromycin or doxycycline regimens and to evaluate whether the efficacy of the azithromycin regimen is inferior to the doxycycline regimen. In the United States alone, approximately 3 million new cases of chlamydia are reported yearly, and the costs associated with their management and complications exceed $2 billion. This study will look at how well medicines given for chlamydia infection work. doi: 10.1136/bmjopen-2018-023808. 2018 Dec 4;8(12):e023808. This study is designed primarily to determine the frequency of chlamydia treatment failure following either azithromycin or doxycycline regimens and to evaluate whether the efficacy of the azithromycin regimen is inferior to the doxycycline regimen.

There is no a significant relationship between failure rate and follow up.Results of meta-regression on the relation between failure rate difference and follow up. The study will enroll 650 males and females age 12-21 years in good health (based on vital signs and provider's clinical evaluation documented in medical records) who are residing in long-term gender-segregated (not co-ed) youth correctional facilities (YCFs) (usual stay >3 weeks) and who are identified as chlamydia-infected would comprise the study population until 306 evaluable subjects are obtained . Study visits will occur during initial enrollment in the study, day 28 after starting treatment, and day 67. Failure rate relatively increased with age.Results of meta-regression on the relation between failure rate difference and age. The midpoint of each line segment shows the failure rate, the length of the line segment indicates the 95% confidence interval in each study, and the diamond mark illustrates the pooled failure rate.A Pooled estimate of failure rate in azithromycin user based on a random effects model in different diseases.

There is no a significant relationship between failure rate difference and age.Results of meta-regression on the relation between failure rate in azithromycin user and follow up. Study procedures will include collection of at least 3 urine samples to test for chlamydia. Both therapies are given as directly observed, and side effects are evaluated at the first follow-up visit (day 28 after study drug initiation). The size of the circles represents the precision of each study. The size of the circles represents the precision of each study.

A secondary aim will be to determine demographic predictors of chlamydia treatment failure following azithromycin or doxycycline treatment, and to explore clinical parameters, which distinguish those with persistent infection.

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chlamydia treatment failure with azithromycin